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Nervous System

Central B (Capsules)
(Valerian / Passiflora / Craetegus)



CONTENT:
Capsules. Capsule contains dry watery-alcoholic extract of Passiflora incarnata L. 25 mg; dry watery-alcoholic extract of Crataegus oxyacantha L. and/or Crataegus monogyna Jacq. (5,5:1) 25 mg; dry watery-alcoholic extract of Valeriana officinalis L. (5:1) 100 mg
 
PHARMACOLOGICAL PROPERTIES:
PHARMACODYNAMICS. Central-B is a combined herbal medicine with sedative effect. Its composition includes three components, dry watery-alcoholic extracts of drug plants: Passion Flower (Passiflora incarnate), Hawthorn (C. oxyacantha and/or C. monogyna) and Valerian (Valeriana officinalis).
 
Passiflora extract contains alkaloids and flavonoid, vitexine. It has mild sedative effect on central nervous system, favours sleep restoration, reduces anxiety and nervousness, has a spasmolytic action on the smooth muscles, improves cardiac performance, has sedative effect.
 
Hawthorn contains flavonoids, choline, acetylcholine, tanning substances, phytoserins etc. It has spasmolytic effect conditioned by selective vasolidating effect on brain and heart due to the presence of triterpenic compounds and flavonoids. It shows hypotensive action and favours normalization of venous pressure, improves function of vessel walls. It has mild sedative action.
 
Valerian extract contains borneol ester and isovalerenic acid. It also contains free valerenic acid, borneol, organic acids, alkaloids (valerin and chatinin), tanning substances, sugars and other biologically active substances. It has sedative action, reduces tension and irritancy typical for mental overstrain and neurasthenia. It has spasmolytic effect.
PHARMACOKINETICS. The effect of this medicine is due to the combined action of its components, thus conducting of kinetic observations does not seem possible.
 
THERAPEUTIC INDICATIONS:
- irritability;
- anxiety;
- anxious feeling and depression;
- sleep disturbance, insomnia.
 
CONTRAINDICATIONS:
- hypersensitivity to the preparation components;
- pediatric use (children under 12 years old).
 
SIDE EFFECTS:
The medicine Central-B is usually well tolerated. Seldom: allergic reactions, asthenia.
 
DOSAGE AND ADMINISTRATION:
Central-B is taken orally following by sufficient quantity of water.
In case of irritability, anxiety, anxious feeling and depression: usual dose 1 to 2 capsules 3 times daily. The maximal daily dose is 6 capsules.
In case of sleep disturbance and insomnia: 2 capsules 30 minutes before going to sleep.
 
OVERDOSE:
Symptoms: vertigo, colic, chest tightness, mydriasis, nausea, vomiting.
Treatment: possible: gastric lavage. Treatment would be carried out symptomatically if necessary.
 
APPLICATION DURING PREGNANCY AND LACTATION:
Drug application during pregnancy and lactation is recommended only if expected benefit to the mother significantly exceeds possible risk to the fetus.
 
PACKAGING:
15 hard gelatin capsules in blister.
1 or 3 blisters in a carton box together with leaflet.
 
 
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